Increased virulence of a novel reassortant H1N3 avian influenza virus in mice as a result of adaptive amino acid substitutionsArticle Published on 2022-10-012023-06-22 Journal: Virus Genes [Category] 조류인플루엔자, [키워드] amino acid substitutions Avian influenza virus H1N3 mouse adaptation virulence. [DOI] 10.1007/s11262-022-01911-x PMC 바로가기
Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses2개의 매우 구별되는 델타 계통 바이러스에 의한 SARS-CoV-2의 빠른 반복 감염Case Reports Published on 2022-09-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitutions change conditions Deletion deletions Delta delta variant genomic had no Health increasingly individual Infection Lineage mutations Patient positive Protective Protein question Rapid Reinfection reinfection. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants singular Spike protein the Spike variant virus [DOI] 10.1016/j.diagmicrobio.2022.115747 PMC 바로가기 [Article Type] Case Reports
Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type referenceSARS-CoV-2 변이체의 구조적 생물정보학 분석은 야생형 참조에 비해 Omicron B.1.1.529 스파이크 RBD에 대해 더 높은 hACE2 수용체 결합 친화력을 보여줍니다Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, [키워드] ACE2 binding affinity Alpha Amino acid amino acid substitution amino acid substitutions Analysis B.1.1.529 binding binding affinity Bioinformatics analysis calibrated characterized COVID-19 pandemic develop Effect hACE2 receptor Halo highest hydrophobicity infected with SARS-CoV-2 Interaction linear molecular dynamics Molecular dynamics simulation molecular dynamics simulations much higher new SARS-CoV-2 occurred omicron pandemic RBD Receptor binding domain receptor hACE2 reveal SARS-CoV-2 variant SARS-CoV-2 variants sequence Spread the RBD the SARS-CoV-2 variant variants VoC wild type [DOI] 10.1038/s41598-022-18507-y PMC 바로가기 [Article Type] Article
SARS-COV-2 RBD (Receptor binding domain) mutations and variants (A sectional-analytical study)SARS-COV-2 RBD(수용체 결합 도메인) 돌연변이 및 변이체(섹션 분석 연구)Article Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 receptor Alpha alpha and delta variants Alpha variant Amino acid amino acid substitutions amino acids amplified B.1.1.529 B.1.1.7 binding domain binding the receptor-binding body pain chill chills circulation Clinical outcome clinical outcomes Clinical sign Clinical signs cross-sectional D614G delta variant domain Effect enrolled essential amino acids Fever Frequency highest host cells identify Infection lung involvement mutant strain Mutation mutations N501Y omicron Omicron variant outcomes Pain pangolin Patient qRT-PCR RBD RBD region Receptor-binding domain SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV2 sequenced spike Spike protein strain T478K the patient the RBD the SARS-CoV-2 variant Variant. variants variants of concern variants of interest Variation viral infection virus VOCs VOIs [DOI] 10.1016/j.micpath.2022.105595 PMC 바로가기 [Article Type] Article
First cases of infection with the 21L/BA.2 Omicron variant in Marseille, France프랑스 마르세유에서 21L/BA.2 오미크론 변종 첫 감염 사례Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Clinical outcome Cluster country deletions Denmark deviation diagnosed distribution emergence England facilitate flattening France Genome genomes incidence Infection initial Interaction Marseille MONITOR N-terminal domain Nepal Next-generation sequencing nucleotide nucleotide substitution nucleotide substitutions omicron Omicron variant Phylogeny predominant qPCR remained resulting SARS-CoV-2 Singapore South Africa southern France Spike protein Surveillance the spike protein Travel variant Variant. viral genome viral genomes [DOI] 10.1002/jmv.27695 PMC 바로가기 [Article Type] Article
Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients의사형 박쥐 코로나바이러스 RaTG13은 SARS-CoV-2 감염 환자의 회복기 혈청에 의해 효율적으로 중화됩니다.Article Published on 2022-05-032022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition affinity Amino acid amino acid substitution amino acid substitutions antibody B.1.351 bat Beta change convalescent sera COVID-19 pandemic demonstrated E484K healthcare Healthcare workers immune evasion infected patient Infection less Mutation neutralisation neutralisation assay neutralisation assays pseudotype RaTG13 RBD Receptor binding domain reducing responsible sarbecovirus SARS-CoV-2 SARS-CoV-2 infected patient sequence similarity Spike mutant spike mutants Spike protein Spike proteins Spike receptor binding domain the RBD vaccination Vaccination strategies variants variants of concern virus virus VoC [DOI] 10.1038/s42003-022-03325-9 PMC 바로가기 [Article Type] Article
Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and OmicronDelta Plus, Iota 및 Omicron에서 SARS-CoV-2 알파 거울 돌연변이로 인한 백신 돌발 감염Article Published on 2022-05-022022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha variant Amino acid amino acid substitution amino acid substitutions Amplicon amplicons Breakthrough infection COVID-19 deep deep sequencing Deep sequencing analysis defined Delta distribution distributions dominant epidemiologically examined Frequency Host human population identify Iota isolate Molecular biology mutant mutant spectra mutants Mutation nasopharyngeal omicron Omicron variants Patient Replication SARS-CoV-2 Sequencing Sequencing analysis Substitution the SARS-CoV-2 Vaccine variant variants Virology Virology. virus [DOI] 10.1172/JCI157700 PMC 바로가기 [Article Type] Article
Human phospho-signaling networks of SARS-CoV-2 infection are rewired by population genetic variantsSARS-CoV-2 감염의 인간 phospho-signaling 네트워크는 인구 유전 변이에 의해 재배선됩니다Article Published on 2022-05-012022-09-11 Journal: Molecular Systems Biology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] alterations Amino acid amino acid substitution amino acid substitutions Analysis ARFGEF2 association Comorbidities contributing to COVID-19 COVID-19 pathology disrupt Evolution Factor Genetic genetic factors Genetic variant Genetic variation Glucose highlight homeostasis Hospitalization Host host defenses host responses Human human genetic variation identify immune responses in viral induce Infection innate immune responses Inter-individual variation interferon interferon response involved kinase leads life cycle MAPK Missense modulated motif motifs nucleotide pathology Pathways phosphorylation site phosphorylation sites protein-protein interaction RNA splicing SARS-CoV-2 SARS-COV-2 infection sequence Sequence motifs severe COVID-19 Signaling signaling pathway signaling pathways Single nucleotide variant SNV SNVs STARD13 TANK TBC1D4 TBK1 translational TRIM28 Viral viral life cycle Viral proteins with COVID-19 [DOI] 10.15252/msb.202110823 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease OutcomesSARS-CoV-2 점 돌연변이 및 삭제 스펙트럼과 다양한 질병 결과와의 연관성Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid amino acid substitution amino acid substitutions Amplicon amplicons Analysis association average complexity consensus sequence coronavirus COVID-19 COVID-19 pandemic COVID-19 severity Deletion deletions develop diagnostic disease diversity index Effects functional Genetic variant genetic variants Haplotype infected patients isolate isolates location Mild mild COVID-19 symptoms Mild disease Mild symptom mild symptoms moderate moderate or severe disease mutant mutant spectra mutant spectrum Mutation mutations nasopharyngeal Nsp12 nsp12 (polymerase) Patient patients with moderate phenotypic Point Point mutation polymerase Region RNA RNA virus RNA viruses SARS-CoV-2 selective pressures Sequencing severe COVID-19 severe disease severity significantly significantly higher Spain spike three-dimensional structure ultradeep sequencing. viral pathogenesis virus [DOI] 10.1128/spectrum.00221-22 PMC 바로가기 [Article Type] Article
Comparative Analysis of SARS-CoV-2 Variants of Concern, Including Omicron, Highlights Their Common and Distinctive Amino Acid Substitution Patterns, Especially at the Spike ORF오미크론을 포함한 우려되는 SARS-CoV-2 변이체의 비교 분석은 특히 스파이크 ORF에서 공통적이고 독특한 아미노산 치환 패턴을 강조합니다Comparative Study Published on 2022-03-292022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acid Alpha Amino acid amino acid substitution amino acid substitutions analysis Beta common Comparative concern COVID-19 Delta dN/dS Evolution Gamma highest homologous hotspot human host Hypothesis Including introduced investigated Lambda Lineage lineages mutated mutations omicron ORF phylogenetic distribution Point mutation Positive selection RBD Receptor binding domain Recombination recurrent mutations residue Sarbecoviruses SARS-CoV-2 significantly higher spike Substitution the Spike vaccination variant variants variants of concern variants of concern. was performed [DOI] 10.3390/v14040707 PMC 바로가기 [Article Type] Comparative Study